Cameroon has received more than 330,000 doses of a new malaria vaccine – the first to be approved by the World Health Organization (WHO).
Health Minister Manaouda Malachie described it as a historic moment.
Kenya, Ghana and Malawi have already started distributing the RTS,S vaccine, which has to be administered in four doses.
Over the next few weeks, deliveries are expected in Burkina Faso, Liberia, Niger and Sierra Leone.
Africa accounts for the vast majority of malaria cases worldwide.
The disease kills more than 600,000 people globally each year, most of them children.